Amicus Therapeutics Making a Difference in the Lives of Patients

Amicus Therapeutics is a biotechnological company recognized globally for their dedication towards the treatment of orphan diseases. The company has been at the forefront of research and treatment of a range of devastating rare diseases.

Amicus Therapeutics was founded in February 2002 and is based in Cranbury, New Jersey. The company is headed by John Crowley, who is the CEO and Chairman of the board. Other key figures include Bradley Campbell, who is the Chief Operations Officer, and William Baird, who is the Chief Finance Officer. Amicus Therapeutics is a publicly traded company under the brand NASDAQ. The company has been on the stock exchange since 2007 after a planned IPO.

Amicus mainly focuses on rare and orphan diseases ( The Chaperone-Advanced Replacement Therapy, otherwise referred to as CHART is the main basis of the company’s product development. Amicus has put an emphasis on enzyme replacement therapies (ERTs). The company’s efforts have earned them accolades. In 2014, Amicus was recognized as the company with the broadest portfolio in terms of small molecule pharmacological chaperones in the entire pharmaceutical industry.

Although they had no marketed products by February 2014, some of the most notable developments from Amicus Therapeutics include migalastat, otherwise known as Galafold. Galafold is a pharmacological chaperone treatment which is aimed at stabilizing endogenous mutant alpha-galactosidase for the treatment of Fabry disease.

Amicus Therapeutics has no manufacturing capabilities and therefore relies on contract manufacturing (WeeklyOpinion). Additionally, the company collaborates with other like-minded firms to come up with treatments for complex diseases. One of its most notable collaborations was with GlaxoSmithKline and JCR Pharmaceutical. The collaboration which lasted from 2010 to 2013 was aimed at investigating co-formulation with recombinant alpha-galactosidase.

It is worth noting that in 2008, the company expanded its activities from its single location in New Jersey to a second research facility in San Diego. Additionally, Amicus got a big financial boost, when they received a US$500,000 grant in 2010 from the Michael J. Fox Foundation. The grant was aimed at supporting studies conducted by Amicus in collaboration with the David Geffen School of Medicine.

In 2013, Amicus went a step further and acquired CallidusBiopharma, which was one of their competitors. The acquisition granted Amicus Therapeutics intellectual and material property for the treatment of Pompe disease.


Osteoarthritis Management from Osteo Relief Institute

Osteoarthritis is described by the wearing out of cartilage, the soft tissue situated between the joints. As cartilage breaks down and wears away, the body bones rub against each other causing pain, stiffness and swelling. After some time, joints lose energy and pain may become very high. While there is no cure, there are many treatment alternatives available for handling joint pain and ensuring that one lives a good life.

Effects associated with osteoarthritis include weight, age, family history and previous exposure. Since osteoarthritis is non-curable and degenerative, a patient’s commitment to self-management is enough to minimize the scope and speed of the condition’s impact. There are a few components of arthritis self-management, in a perfect world used in combination for most desired success and relief.

There are different treatments available for arthritis pain relief. However, all medications involve some danger of developing side effects over a long-term use. It is good that you chat with your doctor about acetaminophen or topical analgesics, to know what might work best for you (HealthGrades). A qualified Physical Therapy professional is an amazing asset to enable you to figure out how to move and deal with your body to limit the pain and portability loss related to arthritis. Finally, when more conservative techniques have failed, a patient may get life from undergoing surgery. Alternatives include joint fusion, minimal obtrusive joint repair, and joint replacements.

If you need the above services, Osteo Relief Institute is the best place to go ( It is located in NJ, 1985 State Route 34 Ste A8, and Wall Township, NJ 07719. This is one place where you will get quality joint injection services. Note that joint injections are intended to decrease pain symptoms to such an extent that patients can take an interest in active recuperation practice and ordinary exercises keeping in mind the end goal to stretch and strengthen the joint. Our orthopedic authority can also confirm your determination when giving a joint injection. The pro will pick from the lower leg, metatarsophalangeal and subtalar joints which are the common joints for injections. We also have an ultrasound machine which is used to direct the injection into that joint.

More about Osteo Relief Institute on Crunchbase

Eli Gershkovitch Pioneers Award Winning Craft Beer Surge in Canada

Canadians love their beer. Like hockey, beavers, and maple leaves, beer is considered an essential part of the Canadian identity, to the tune of 9 billion dollars a year. The last decade, long after Eli Gershkovitch opened Steamworks Brewing in Vancouver, has been an especially good one for craft beers in Canada. Canadian brews are winning awards and gaining market share across the country.


According to the Canadian Ministry of Agriculture, even as overall beer consumption dropped, the consumption of craft beers increased between 2004 and 2012 (Twitter). Some industry analysts believe craft beers are gaining attention because they focus on a flavorful, cosmopolitan experience directly tied to favorite flavors and local pride.


The 2017 U.S. Open Beer Championship showed just how far Canadian craft beer has come. Canada took home 24 awards, including 10 gold medals. Eli Gershkovitch, a Canadian craft brewer out of Vancouver, has been an instrumental part of this change, having worked tirelessly since 1995 to put Canadian craft brewing on the map.


There are many craft breweries across Canada winning awards. Some hail from the East Coast and others from the West Coast. A few notables from the East would be Propeller from Nova Scotia, and La Fin de Monde and McAuslan in Quebec. From the West Coast, favorites include Electric Unicorn and Eli Gershkovtich’s Steamworks.


Eli Gershkovitch is the brewing mastermind behind Steamworks ( Gershkovitch was an unlikely brewing company CEO. He took a tour of Europe in the early 90s and sampled microbreweries in Germany that tasted like nothing he had ever experienced before. While Eli Gershkovitch was hesitant to give up his law school aspirations, he never forgot the lessons he learned there in Europe.


Still, his legal knowledge gave him a crucial edge when he opened up the first ever Canadian steam brewing company. Legal complexities and lack of knowledge had prevented anyone else from trying it, but the pioneer flavor intrigued many Canadians, who had been accustomed to watery, mass-produced tastes.


Now, Steamworks Brewing is a Vancouver hotspot for craft beer connoisseurs and Eli Gershkovitch is a hero of the Canadian brewing industry.



Edisoft is a global software company that was founded in 1995. The company serves partners and clients internationally with its regional offices in the USA and Canada. Right from the beginning, the company was interested in supporting medium-sized and small businesses to easily trade and or connect with their business partners through the provision of unparalleled EDI way outs. The company developed a key product that integrated full-featured EDI functionality with the major ERP and accounting software systems.



The company formed a group of software and EDI experts who were based in its Toronto headquarters. The team initiated the R&D, a program which was so intensive. This program resulted in the formation of a number of Supply Chain Solutions which is a number of products so-called Edisoft Merchant ( This Edisoft Company Supply Chain Solutions which also all rounded includes; Merchant XChange™, Edisoft Merchant and also Merchant QuikPAK™. The Edisoft Merchant™ product offers a platform for integrated EDI solutions for turnkey while the Merchant QuikPAK™ product is used in warehouses for the automation of the pick, print, pack and the shipment stages and also a platform for the automation of the order promotions. On the other hand, Merchant XChange™ product provides a platform for Value Added Network (VAN) FOR Edisoft Company.



Initially on-time performance measurement the major key performance indicator (KPI) for departments that were concerned with transportation (Crunchbase). The scorecards were reviewed on a quarterly basis. Today KPIs provides a number of great practices such as those that cut across the financial, physical and the supply chain regulatory aspects. There is a great evolution of GPS datasets, real-time tracking, The Internet of things (IOT) and the international trading partners that is technology enabled through the use of mobile solutions. Complete, timely and accurate information from all the relevant parties helps in appropriate decision-making. Data quality management program and an evaluation criterion are required in evaluating KPIs that has a very big data.



When leveraging big data, the opportunities go far much beyond the carrier performance improvement. KPIs Best-in-practice traverses business and trading partners’ processes. The companies can achieve agile, a more predictable, cost-efficient and compliant supply chain through the analysis of the KPIs factors contributing to variability and the end-to end supply chain.

Glen Wakeman: The Man Who Is Helping To Raise A New Generation of Entrepreneurs

Glen Wakeman is a revolutionary businessman, entrepreneur, and mentor of other entrepreneurs who is also the co-founder and CEO of LaunchPad Holdings, LLC. Glen received his Bachelor’s of Science degree in Finance and Economics from the University of Scranton in 1981 and earned his MBA in Finance while studying at the University of Chicago in 1993. He has over 20 years of experience in the finance and business sector and began his early career at GE Capital.

 5 Steps To Better Performance

Glen Wakeman’s 5 step performance methodology has been hailed as a proven system that can be applied to a variety of industries, and it includes paying more attention to leadership, execution in business, risk management, governance, and human capital. Glen discovered that his system works because he has not only used it himself but has also helped to improve businesses with 17,000+ staff members and $15 billion in assets. Not only has he helped to mentor young entrepreneurs with great success, but he also has guided plenty of M&A’s, start-ups, new market entries, and divestitures to more profit (Twitter). As more and more entrepreneurs and companies apply his ingenious system, more of them are happier with their growth and success.

Glen Wakeman Blogs To Help Real People Solve Real Problems

Glen knows that in today’s world reaching people through a blog is crucial to helping them overcome their issues. His experience with investing and writing has inspired him to share his knowledge through his blog. Whether he is writing about global events, international fiscal matters, business transformation, emerging markets, leadership, or capital raising and angel financing, Glen is reaching people and instructing them about what matters most. His blog post titled, “A New Angle on Social Media” was a popular one and quickly explained how to use social media better in order to better tap into customer’s minds. Instead of blasting out posts constantly to social media followers, Glen recommends trying listening to them in order to understand them better.

Having a Big Heart for Others

If you were falsely arrested, sued those who arrest you, win a case against them and awarded close to four million dollars by the court, what would you do with the money? Would you buy a new car, a house or tour the world? Would you ever think of starting a charity to fight for other people’s rights and freedom? Learn more about Jim Larkin and Michael Lacey:

I doubt. Yet, that is exactly what Michael Lacey and Jim Larkin did. They started a charity fund, the Lacey and Larkin Frontera Fund, with their settlement money.

This is how it happened: Michael Lacey and Jim Larkin were two veteran journalists. The two were fearless in their work. They dedicated their work in championing for human rights. They were on the forefront of defending the oppressed minority by articulating their suffering. They also unearthed those behind the mistreatment of the minority and made sure that the public knew about them.

Their daring spirit led to their arrest after they wrote a story about a notorious sheriff, Joe Arpaio. Sheriff Joe had presented himself as untouchable, a demi-god who used his power and office to discriminate, mistreat and abuse minority groups. Upon the running of the story, the Sheriff ordered for their arrest and prosecution. However, as the old adage goes, the truth will always prevail. Michael and Jim were later released from jail after it was found out that they had been falsely arrested and accused.

They then sued the county. The court favored them and awarded them 3.75 million dollars as resettlement. Having been arrested for fighting for the rights of the minorities, Michael and Jim decided to use the resettlement money to set up the Lacey and Larkin Frontera Fund to help other groups that advocate for the rights of the minorities with funds.

Over the years, this organization has effortlessly been working in makings sure that the rights of the immigrants are respected and their dignity preserved. The organization operates in Arizona and along the Mexican border.

Many countries lack legal systems that uphold the civil rights, human and migrant rights. That, coupled with huge legal fees has left most migrants and refugees to face the blunt force law in certain countries in silence. Some have been arrested, accused falsely and even jailed because they lacked people to defend them. Others lacked significant knowledge regarding the laws of the country. Read more: Jim Larkin | Crunchbase and Village Voice Media | Wikipedia

To be of assistance in organizing lawyers and law students succeed in fighting for both human and legal rights of refugees through legal help and policy advocacy, the International Refugee Assistance Project was formed. The project empowers members with legal knowledge on how to articulate the rights of refugees through legal means.

Another organization that works similar to International Refugee Assistance Project is the Immigration Legal Resource Center, a national resource center that helps in training lawyers and advocates, as well as communities to advocate for the rights and well-being of immigrants. It also participates in county, state and federal advocacy work and has been key in calling for the rights of immigrants and minorities.

Alexandre Gama, the Face of Neogama

     Alexandre Gama is a Brazilian advertising entrepreneur. He is a very skilled businessman with creativity and professionalism in both Advertising and Publicity. There are about 20 largest advertising agencies in Brazil, and among them is Neogama, an agency that Gama founded in 1999 and is currently its CEO and CCO.

Alexandre Gama graduated from Fundação Armando Alvares Penteado (FAAP), with a degree in Publicity and Advertising. The Brazil communication industry felt his presence when he started representing it after he joined ABAP. Since then, Gama has worked with other companies like BBH, DM9, among others. It is when he was the CEO of BBH that Gama became the first Brazilian to be on the leader board of global communication agencies. In 2002, Alexandre associated the two companies; Neogama and BBM, the London branch. In 2016, however, after 14 years of activity, Gama cut off the BBM network and renamed it Neogama. He showed a lot of dedication to the success of the company and put both his heart and hard work into it.

His career has had waves of successes. He has received an astounding number of awards over the years, among which are the most prestigious in Brazil. He was elected Officer of Agency of the Year, in 2006; and he received a prize for being the entrepreneur of the year, as well as a successful manager of the communications industry in 2007. Between 2009 and 2017, he has received several other awards like the prestigious Golden Lion award, which he has been accorded more than once.

Alexandre Gama is a successful entrepreneur with skills; talent of managing and professionalism in advertising.

George Soros’ History of Progress

George Soros can point to a specific point in time during which he developed the foundation for the values he has today. Born in Hungary, George Soros and his family were there when Nazis invaded the country and occupied their very homes for a full year. Over that year more than 500,000 Hungarian Jews would be personally and horrifically killed by the Nazi party. Soros and his family were lucky to escape and emigrate to London. During that formative year Soros saw first hand what the dangers of blind nationalism can do to a country and how it can effect innocent people. Now, George Soros is a champion of the people and one of the most prolific and progressive billionaires in the world. Let’s dig deeper into the person that Soros has become.

At 87 years old George Soros has not slowed down at all, despite the enormous burden he has worked under for the past half of a century. After leaving Hungary and emigrating to London George Soros would spend years working multiple jobs, focusing on paying his way through school at the London School of Economics. Here George Soros would read the works of Karl Popper in the title, ‘Open Society and Its Enemies’. Combined with his already negative views toward blind passionate nationalism, Soros came to embrace the world view of an open society that focuses on elevating everyone within it. This obviously put Soros at odds with the notion of capitalism and that led him to pen an intricate op-ed for the Atlantic which detailed the very threats of capitalism.

Outside of his thoughts on capitalism George Soros has spent the vast majority of his life focusing on spreading his progressive ideals around the world. Soros started up the Open Society Foundations in 1979 and since then he has been working non-stop. Over the past 30+ years the Open Society Foundations has donated over $12 billion to countries that were deeply in need. Soros has given back to South Africans who struggled through apartheid. He worked in the ’80s with the Communist Eastern Bloc and he has also helped the Roma people. Most of all Soros knows that in order for society to progress we must all be in it together. That is why he’s worked so steadfastly toward spreading equality, education, and transparent governing wherever he could.

Now in the United States George Soros is making a name for himself as a powerful Democratic donor. As one of the wealthiest progressives in the world Soros is the donation spigot that liberals need in order to stay competitive with the free-spending Republican party. George Soros has stepped up in unique opposition to Donald Trump’s disastrous presidency.

George Soros Social Media:

Why JHSF has been very important to the real estate investors

The successful operation of JHSF

As a leading company in the real estate sector in Brazil, investors have always applauded the name of the company for the good work that it has done. The company is dedicated to providing quality housing services o its customers within and without the country. Several of the existing customers are people from the United States who are interested in investing in Brazil. The company provides good services to the clients interested in commercial or residential properties. Other than housing, JHSF is focused on general property servicing. Most of the services offered include luxury hotels, guest rooms, conferences and several others. The investors looking for real estate investments in Brazil have always had an easy time in their search.

The need for quality

Since its inception, JHSF has had a deep desire in giving quality services to the clients. The services are not limited to specific properties or people of specific financial status, but they open to people of every economic class. The company has maintained the current high rating because of service quality. Satisfaction of the client is the primary goal of the operation. With this focus, the company has been marketing its services throughout the country. For accountability, the company has constantly been selling shares to different Brazilian companies and individuals. Being a corporation, the shareholders demand quality services to the customers to keep the trust and the ratings.

The exceptional leadership by José AuriemoNeto

José AuriemoNeto started working in the company in 1993. During this time, Neto was just a regular employee who was looking for a place in the market. The fact that he stayed with the company for long gave him an opportunity to rise through the ranks. Later in his career, José AuriemoNeto was promoted to the position of the CEO. It was in his epoch as the CEO that the company started registering impressive improvements. Neto introduced a leadership of inclusivity where all the employees felt like a part of the company. The leadership style that Neto introduced allowed different employees to share their ideas on how the company can be improved. The suggestions have so far led to an improvement in the company.

Julia Jackson and Cambria Seeds of Empowerment

Julia JacksonCambria Seeds of Empowerment are a nonprofit that was founded by Julia Jackson of Jackson-Family Wines. She is one of the talented proprietors of the award winning company and is also committed to paying it forward with the Cambria foundation. They are focused on highlighting women who have successfully overcome adversity.Barbara Banke is Julia Jackson’s mother and has proved to be an extraordinary role model for her. Jackson realizes what an incredible advantage this has been for her and wishes to provide the same opportunity for other girls and young women with the foundation. She admires her mother’s business sense and ability to run the company. She also relays that her mother is a very authentic person with a strong sense of self. The Cambria Seeds of Empowerment foundation are all about celebrating Warrior Women. These types of women effectively deal with adversity and life’s hardships while also displaying strength as a woman in leadership roles with significant impact. There are three traits that characterize these women and they are equality, community, and spirit. Julia Jackson

Cambria awards cash grants to organizations that exhibit these qualities. Julia Jackson strongly feels that there aren’t enough positive role models for young women to look up to in the media. Cambria hopes to remedy that by highlighting those women who excel in the face of adversity and show strong leadership in business.Formal education was very important to Jackson and she achieved a Bachelor of Arts degree in Studio Art from Scripps College. Here, she found an opportunity to develop her artistic side and later secured a Certificate in General Management from the Stanford Graduate School of Business.Champ de Rêves is one brand that Jackson-Family produces and its claim to fame is their production of Pinot Noir. This is a premier product of the high altitude conditions of Anderson Valley in Mendocino County. Jackson-Family specializes in crafting wines with remarkable distinction from unique growing conditions and this is a fine example.